Predict drug permeability to blood–brain-barrier from clinical phenotypes: drug side effects and drug indications
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چکیده
منابع مشابه
Exploring the Relationship Between Drug Side-Effects and Therapeutic Indications
Therapeutic indications and drug side-effects are both measureable human behavioral or physiological changes in response to the treatment. In modern drug development, both inferring potential therapeutic indications and identifying clinically important drug side-effects are challenging tasks. Previous studies have utilized either chemical structures or protein targets to predict indications and...
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Inferring potential therapeutic indications and identifying clinically important side-effects are both important and challenging tasks in modern drug development. Previous studies have utilized drug chemical structures and protein targets to construct predictive models for both tasks. According to our study, the drug therapeutic information itself is highly predictive for side-effects, and drug...
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Drug-drug interactions (DDIs) are a common source of preventable medical errors in inpatient and outpatient settings of both developed and developing countries. When two or more drugs are simultaneously prescribed, interactions between their effects may result in preventable adverse events such as damages to vital organs, frequent hospitalizations, prolonged length of hospital stay, and increas...
متن کاملDrug-Drug Interaction Clinical Decision Support Systems: Advantages, Challenges and Barriers, and Strategies to Overcome Them
Drug-drug interactions (DDIs) are a common source of preventable medical errors in inpatient and outpatient settings of both developed and developing countries. When two or more drugs are simultaneously prescribed, interactions between their effects may result in preventable adverse events such as damages to vital organs, frequent hospitalizations, prolonged length of hospital stay, and increas...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2016
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btw713